| 发明名称 |
METHOD FOR IMPROVING THE OXYGEN-RELEASING ABILITY OF HEMOGLOBIN TO ORGANS AND PERIPHERAL TISSUES IN HUMAN BODIES |
| 摘要 |
A method for improving the oxygen-releasing ability of hemoglobin to organs and peripheral tissues in human bodies is disclosed by administering ferulic acid to a subject in need thereof to improve the oxygen-releasing ability of hemoglobin to the organs and the peripheral tissues in human bodies. Ferulic acid forms a hydrogen bond with αVal1 of hemoglobin, stabilizing the α1/α2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin and hemoglobin-based blood substitutes in the low oxygen affinity “T” state and facilitating the oxygen release to the organs and the peripheral tissues. |
| 申请公布号 |
US2016058722(A1) |
申请公布日期 |
2016.03.03 |
| 申请号 |
US201514840548 |
申请日期 |
2015.08.31 |
| 申请人 |
NATIONAL SUN YAT-SEN UNIVERSITY |
发明人 |
WANG Chia-Chen;ZULFAJRI Muhammad;YU You-Qing |
| 分类号 |
A61K31/192 |
主分类号 |
A61K31/192 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for improving the oxygen-releasing ability of hemoglobin to organs and peripheral tissues in human bodies, by administering ferulic acid to a subject in need thereof to improve the oxygen-releasing ability of hemoglobin to the organs and the peripheral tissues in human bodies, wherein ferulic acid forms a hydrogen bond with αVal1 of hemoglobin, strengthening the α1/α2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin in the low oxygen affinity “T” state and facilitating the oxygen release to the organs and the peripheral tissues. |
| 地址 |
Kaohsiung TW |
