| 摘要 |
PROBLEM TO BE SOLVED: To provide a CCR-2 and CCR-5 receptor inhibition activator associated with newborn blood vessels for prophylaxis or therapy of diseases of the posterior segment of the eye, i.e., diseases in a vitreous body, retina, choroid, sclera or optic nerve, associated with neovascularization.SOLUTION: The present invention relates to a prophylactic or therapeutic agent for diseases of the posterior segment of the eye, which contains, as an active ingredient, a 3-amino-2-oxopyrrolidine derivative represented by formula (1), an enantiomer thereof, or a pharmaceutically acceptable salt thereof. [R, Rand Rare each independently H, a lower alkyl group, or a halogen atom-substituted lower alkyl group; Ris H, a halogen atom, a lower alkyl group, or a halogen atom-substituted lower alkyl group; Ris an unsubstituted or R-substituted nitrogen-containing bicyclic aromatic ring group; and Ris a halogen atom, a lower alkyl group, or a halogen atom-substituted lower alkyl group.]SELECTED DRAWING: None |
