摘要 |
QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGIuR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE Abstract (R2)n The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, RQ, -L-, R1, n, R2, and R3 are as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs ), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BUNGARD, CHRISTOPHER JAMES;CONVERSO, ANTONELLA;DE LEON, PABLO;HANNEY, BARBARA;HARTINGH, TIMOTHY JOHN;MANIKOWSKI, JESSE JOSEF;MANLEY, PETER J.;MEISSNER, ROBERT;MENG, ZHAOYANG;PERKINS, JAMES J.;RUDD, MICHAEL T.;SHU, YOUHENG |