SYSTEM AND METHOD FOR IMAGING BIOMARKERS INDICATIVE OF CARIDAC THERMAL ABLATION LESIONS

摘要

Described here are systems and methods for visualizing thermal ablation lesions by imaging specific chemical compounds that are created during thermal ablation procedures, such as cardiac ablation procedures. When a cardiac ablation procedure is performed, a central area of coagulative necrosis is created at the treatment site. This necrotic region is surrounded by layers of tissues with ultra-structural and electrophysiological changes. Two particular changes include the denaturation of proteins and the formation of ferric iron containing chemical compounds, such as methemoglobin and metmyoglobin. The formation of and distribution of such chemical compounds can be imaged with the appropriate systems and methods. Accordingly, these chemical compounds can be utilized as biomarkers that indicate the presence and physical characteristics of thermal ablation lesions. Imaging can be performed using magnetic resonance imaging, optical imaging, or photoacoustic imaging, as examples.

主权项

1. A method for imaging a biomarker indicative of thermal ablation using a medical imaging system, the steps of the method comprising:
a) acquiring data with the medical imaging system; and b) producing from the acquired data, an image that depicts a biomarker indicative of a thermal ablation.