Process for producing 3-hydroxybutyric acid or salt thereof

摘要

The invention provides a process for producing 3-hydroxybutyric acid or a salt thereof. The process includes (1) culturing one or more halophilic bacteria belonging to the genus Halomonas under aerobic conditions in a medium containing an inorganic salt and one or more organic carbon sources; (2) changing the culture conditions from aerobic culture to microaerobic culture, and culturing bacterial cells of the halophilic bacteria to produce 3-hydroxybutyric acid or a salt thereof in a culture medium; and (3) collecting the 3-hydroxybutyric acid or the salt thereof from the culture medium.

主权项

1. A process for producing 3-hydroxybutyric acid or a salt thereof, the process comprising the following steps (1) to (3):
(1) step 1 of culturing one or more halophilic bacteria belonging to the genus Halomonas under aerobic conditions in a medium containing an inorganic salt and one or more organic carbon sources; (2) step 2 of changing the culture conditions in step 1 from aerobic culture to microaerobic culture, and culturing bacterial cells of the halophilic bacteria to produce 3-hydroxybutyric acid or a salt thereof that is secreted from the bacterial cells into a culture medium; and (3) step 3 of collecting the 3-hydroxybutyric acid or the salt thereof from the culture medium obtained in step 2.