Method for forming mesoporous silica nanoparticles, mesoporous silica nanoparticles, and applications thereof

摘要

A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.

主权项

1. A method comprising:
providing a suspension of mesoporous silica nanoparticles, wherein the mesoporous silica nanoparticles comprise areas of low polymeric density and areas of high polymeric density; fractionating the mesoporous silica nanoparticles suspension to yield size-fractionated mesoporous silica nanoparticles; differential etching of silica from areas of low polymeric density within the size-fractionated mesoporous silica nanoparticle; and re-depositing the silica in areas of higher polymeric density existing near a surface of the size-fractionated mesoporous silica nanoparticles to produce mesoporous silica nanoparticles having a morphology that changes from porous to hollow and wherein said nanoparticles are configured to receive one of a therapeutic agent and an imaging material.