| 主权项 |
1. A compound of the general formula (I): or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, wherein R1 is selected from R2 is hydroxy, heteroalkyl, alkoxy, polyalkoxyalkyl, NR3R4, (NHS(O)2-m-(C6H4)N3, or Xaao; R3 and R4 are each and independently of each other selected from the group consisting of hydrogen atom, hydroxy, alkyl, heteroalkyl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aralkyl, or heteroaralkyl; Xaa is Gly, a conventional D,L-, D- or L-amino acid, a non-conventional D,L-, D- or L-amino acid, or a 2- to 10-mer peptide, wherein Xaa is joined to —C(O) by an amide bond; o is an integer selected from 1 to 10; B is CH2, 0, or S; m is an integer from 1 to 6; T, U, and W are each —CH2CH2—; V is cis or trans —CH═CH—; X is absent, CH2, and NR5; Z is selected from CH2, and NR5′; R5 and R5′ are each and independently of each other selected from the group consisting a hydrogen atom, a hydroxy, alkyl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aralkyl, heteroaralkyl group; Y is —C(O)—, —C(O)—C(O)—, or —S—; and n is an integer from 0 to 6. |
