Compositions comprising acidic extracts of mastic gum

摘要

The invention relates to compositions and formulations comprising isolated acidic fraction of mastic gum and uses thereof for treating impaired neurological functions as well as wound and tissue repair.

主权项

1. A composition comprising an effective amount of an isolated acidic fraction of mastic gum, and a pharmaceutically acceptable carrier; wherein the isolated acidic fraction is obtained by a process comprising the steps of:
(a) treating the mastic gum with a polar organic solvent; (b) isolating a fraction soluble in said polar organic solvent; (c) optionally removing said polar organic solvent; (d) treating the soluble fraction obtained in step (b) or (c) with a non-polar organic solvent, (e) isolating a fraction soluble in said non-polar organic solvent; (f) optionally removing said non-polar organic solvent; (g) dissolving the fraction obtained in step (f) in an organic solvent; (h) treating the solution obtained in step (g) with a basic aqueous solution so as to obtain a basic aqueous fraction; and (i) acidifying the basic aqueous fraction obtained in step (h) with an acid solution so as to obtain an acidified aqueous solution; wherein the isolated acidic fraction of mastic gum is characterized in that it is soluble in at least one polar organic solvent and in at least one non-polar organic solvent, and wherein said fraction is substantially devoid of compounds which are soluble in said polar organic solvent but insoluble in said non-polar organic solvent, wherein the acidic fraction is obtained from an isolated fraction of mastic gum that is soluble in at least one polar organic solvent and at least one non-polar organic solvent by an acid-base extraction, thereby separating the isolated acidic fraction from the non-acidic fraction of mastic gum that is soluble in at least one polar organic solvent and one non-polar organic solvent.