| 发明名称 | Regulators of NFAT and/or store-operated calcium entry | ||
| 摘要 | Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of proteins involved in the calcineurin/NFAT axis. | ||
| 申请公布号 | US9271997(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201313761444 | 申请日期 | 2013.02.07 |
| 申请人 | THE CHILDREN'S HOSPITAL CORPORATION | 发明人 | Rao Anjana;Hogan Patrick;Sharma Sonia |
| 分类号 | C12N15/113;A61K31/713 | 主分类号 | C12N15/113 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Nixon Peabody LLP ;Resnick David S. |
| 主权项 | 1. A method of modulating NFAT activity in a subject in need thereof, the method comprising administering a therapeutically effective amount of a pharmaceutical composition comprising an agent that inhibits the expression of a TMEM110 gene, wherein the agent is a nucleic acid inhibitor which inhibits gene expression. | ||
| 地址 | Boston MA US | ||