发明名称 Ethynyl derivatives as positive allosteric modulators of the mglur5
摘要 The present invention relates to ethynyl derivatives of formula I X, G, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
申请公布号 IL228835(A) 申请公布日期 2016.02.29
申请号 IL20130228835 申请日期 2013.10.10
申请人 F. HOFFMANN-LA ROCHE AG 发明人
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