SUBSTITUTED 4-{[4-(3,3-DIOXIDO-1,3-BENZOXATHIOL-6-YL)ARYLOXY]METHYL}PIPERIDINES AS GPR119 RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING AND USING THEM

摘要

FIELD: medicine.SUBSTANCE: compounds have the property of a GPR119 receptor agonist and can be used as an active ingredient for pharmaceutical compositions in the form of tablets, capsules, injections, ointments, rectal suspensions and gels presented in a pharmaceutically acceptable pack, in treating metabolic diseases such as metabolic syndrome, diabetes mellitus, and obesity. In the general formulaR=H, (C-C)alkyl, halogen-substituted (C-C)alkyl, acyl specified in a group of C-CalkylC(=O)- or phenyl(C=O)-, substituted heteroaryl representing an aromatic monocyclic group with two nitrogen atoms, which is substituted by a halogen atom or C-Calkyl, (C-C)alkylsulphonyl, phenylsulphonyl; R1, R2, R3, R4 represents hydrogen or one or two substitutes simultaneously specified in a halogen, (C-C)alkyl, halogen-substituted (C-C)alkyl, (C-C)alkylsulphonyl, a cyano group.EFFECT: improving the properties.8 cl, 1 dwg, 8 tbl, 15 ex