发明名称 |
Fc receptor binding proteins |
摘要 |
Disclosed is an isolated antibody comprising a light chain variable region (VL) and a heavy chain variable region (VH), wherein the antibody binds to human FcRn; and wherein the VL comprises: (i) a VL CDR1 comprising the amino acid sequence TGTGSDVGSYNLVS (SEQ ID NO: 14); (ii) a VL CDR2 comprising the amino acid sequence GDSQRPS (SEQ ID NO: 15); and (iii) a VL CDR3 comprising the amino acid sequence SSYAGSGIYV (SEQ ID NO: 12) or ASYAGSIYV (SEQ ID NO: 13); and the VH comprises: (i) a VH CDR1 comprising the amino acid sequence EYAMG (SEQ ID NO: 22); (ii) a VH CDR2 comprising the amino acid sequence SIGSSGGQTKYADSVKG (SEQ ID NO: 23); and (iii) a VH CDR3 comprising the amino acid sequence LAIGDSY (SEQ ID NO: 24). Further disclosed is the use of said antibody in the manufacture of a medicament for modulating an FcRn activity or for treating an autoimmune disorder. |
申请公布号 |
NZ618046(A) |
申请公布日期 |
2016.02.26 |
申请号 |
NZ20120618046 |
申请日期 |
2012.06.01 |
申请人 |
DYAX CORP. |
发明人 |
SEXTON DANIEL J.;TENHOOR CHRISTOPHER;VISWANATHAN MALINI |
分类号 |
A61K39/395;C07H21/04;C07K16/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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