TUMOR VASCULAR DISRUPTING AGENT POLYPEPTIDE, GENE, EXPRESSION VECTOR, AND USE THEREOF

摘要

Provided are a tumor vascular disrupting agent polypeptide, gene, expression vector, and use thereof. The polypeptide has the amino acid sequence as shown by SEQ ID No: 1, and comprises a truncated tissue factor (tTF), a tumor-targeting molecule (pHLIP), and 5 amino acid linkers. The polypeptide can be positioned to the surface of a tumor vascular endothelial cell by means of the pHLIP, and provides the blood coagulation feature of the tTF, thereby disrupting the blood supply to the tumor area and treating tumor.