| 发明名称 |
SYSTEM AND METHOD FOR ITERATIVE DETECTION OF BIOLOGICAL MOLECULES |
| 摘要 |
A system for the iterative detection of biological molecules includes a probe, and a fluorophore tethered to the probe with an azide-based linker. The linker is configured to be cleaved in the presence of tris(2-carboxyethyl)phosphine (TCEP), and the on/off ratio between a signal measured before treatment with TCEP and a signal measured after treatment with TCEP is at least about 20:1. |
| 申请公布号 |
US2016054308(A1) |
申请公布日期 |
2016.02.25 |
| 申请号 |
US201514820875 |
申请日期 |
2015.08.07 |
| 申请人 |
Guo Jia |
发明人 |
Guo Jia |
| 分类号 |
G01N33/542 |
主分类号 |
G01N33/542 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A system for iterative detection of biological molecules, comprising:
a probe; and a fluorophore tethered to the probe with an azide-based linker; wherein the linker is configured to be cleaved in the presence of tris(2-carboxyethyl)phosphine (TCEP), and wherein the on/off ratio between a signal measured before treatment with TCEP and a signal measured after treatment with TCEP is at least about 20:1. |
| 地址 |
Tempe AZ US |
