PYRAZOLE COMPOUND

摘要

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT 2 C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT 2 C inverse agonistic action comprising Compound (1) :
or a pharmaceutically acceptable salt thereof
wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen or C 1-6 alkyl etc.; R 5 is C 4-7 alkyl or -(CR 8 R9) r -E; R 6 , R 7 , R 8 and R 9 are independently hydrogen, fluorine or C 1-6 alkyl; A is C 6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C 3-8 cycloalkyl or C 6-10 aryl etc.; L is oxygen, sulfur or -NR 10 -; n is 1, 2 or 3; R 10 is hydrogen or C 1-6 alkyl etc.; and X is hydrogen or halogen etc.