| 摘要 |
An injectable preparation comprising an antibody or antibody fragment, for use in a method of treating or reducing the risk of rheumatoid arthritis in a human. The antibody or antibody fragment specifically binds an IL6R protein that comprises a mutation Asp358Ala or Val385Ile in SEQ ID NO. 78. The antibody or antibody fragment comprises a human gamma-1 heavy chain constant region that comprises an amino acid selected from the group consisting of an Asp at position 204 shown in SEQ ID NO. 81 and a Leu at position 206 shown in SEQ ID NO. 81. The human comprises an IGHG1*01 human heavy chain constant region gene segment or the human expresses antibodies comprising human gamma-1 heavy chain constant regions comprising said amino acid. The human further comprises a nucleotide sequence encoding an IL6R protein comprising said Asp358Ala or Val385Ile in SEQ ID NO. 78. |
