Nanofunctional silica particles and manufacturing method thereof

摘要

Provided are nanofunctional silica particles having excellent functionality and quality, and capable of being mass-produced at low costs. According to the present invention, there are provided nanofunctional silica particles including a coating layer containing one or more silica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), and aminopropyl trimethoxysilane (APS); and functional particles in the coating layer, and being used in imaging, assay, diagnosis, treatment or the like, medicine or bioresearch.

主权项

1. Nanofunctional non-porous silica particles, comprising a shell made mainly of silica obtained from one or more organosilica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), aminopropyl trimethoxysilane (APS), and aminopropyl triethoxysilane (APES); and a core, in the shell, having a diameter of 2 to 200 nm and containing one or more species selected from the group consisting of a magnetic material, gold colloid, a quantum dot, gadolinium-containing particles, and an imaging functional material-containing liquid, wherein a thickness of the shell is more than 5 nm and less than 100 nm and wherein a functional compound chosen from fluorescent material or an imaging agent is held in the shell and in the core.