发明名称 |
PROCESS OF ENANTIOMERIC RESOLUTION OF D,L-(.PLUSMINUS.)-THREO-METHYLPHENIDATE |
摘要 |
A process for preparing the d-threo isomer of methylphenidate hydrochloride which includes (i) resolving a racemic mixture of racemic threo-methylphenidate hydrochloride with a less than stoichiometric amount of tertiary amine base to obtain a methylphenidate - chiral acid salt, (ii) basifying the methylphenidate - chiral acid salt to obtain methylphenidate free base, and (iii) converting the methylphenidate free base into d-threo-methylphenidate hydrochloride |
申请公布号 |
CA2674451(C) |
申请公布日期 |
2016.02.23 |
申请号 |
CA20072674451 |
申请日期 |
2007.12.19 |
申请人 |
ARCHIMICA, INC. |
发明人 |
KALININ, ALEXEI;QIU, GUOFANG;MARREN, THOMAS J.;ALDRED, JR., JAMES E.;JI, YU |
分类号 |
C07D211/34 |
主分类号 |
C07D211/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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