Compositions and methods for treatment of thrombosis and for prolonging survival of stored platelets

摘要

Provided herein are methods and compositions, including pharmaceutical compositions, for treating thrombosis, vascular inflammation, and thrombocytopenia. The methods and compositions of the present invention are also useful for extending the useful storage shelf life of platelets.

主权项

1. A cyclic conjugated peptide (CCP) comprising the amino acid sequence Ala-Cys-Thr-Glu-Arg-Met-Ala-Leu-His-Asn-Leu-Cys-Gly-Gly-Lys, (SEQ ID NO: 4), wherein the C-terminal lysine residue is covalently linked with a polymeric compound and wherein said CCP has the ability to bind in a non-covalent manner to human GPIbα, and said CCP exhibits more potent inhibition of platelet binding to Mac-1 integrin receptors compared to a cyclic peptide comprising the same amino acid sequence, without a covalently linked polymeric compound.