USE OF OPIOID ANTAGONISTS TO ATTENUATE ENDOTHELIAL CELL PROLIFERATION AND MIGRATION

摘要

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists, such as methylnaltrexone or alvimopan. The disorders to be treated alone or in combiantion with for instance - anticancer agents (5-f luorouracil or bevacizumab) are i.a. cancer, diabetes, sickle cell anemia, vascular wound, proliferative retinopathy.