Bicyclic heterocyclic compound

摘要

To provide a compound useful as an active ingredient of a pharmaceutical composition for treating 11β-hydroxysteroid dehydrogenase type 1-related diseases such as dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance and the like.;[Means for Solution] A bicyclic heterocyclic compound (the bicyclic heterocycle is formed when a cyclohexane ring is fused with a 5- to 6-membered monocyclic heterocycle that has only a nitrogen atom as a hetero atom) substituted with an acylamino group such as a (hetero)aroylamino group or the like or a pharmaceutically acceptable salt thereof was found to have an excellent selective inhibitory action against 11β-HSD1. Accordingly, the bicyclic heterocyclic compound of the present invention can be used for treating dementia, schizophrenia, depression, pain (particularly, neuropathic pain or fibromyalgia), diabetes (particularly, type II diabetes mellitus), insulin resistance, and the like.

主权项

1. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: wherein: ring A is a 5- to 6-membered monocyclic heterocycle which may be substituted and has only nitrogen atom(s) as the hetero atom; wherein the atoms in the position where the ring is fused with the adjacent ring are carbon atoms; R1 is lower alkyl, halogeno-lower alkyl, or cycloalkyl which may be substituted; R2 is halogen or lower alkyl; R3 is aryl, heteroaryl, or lower alkylene-heteroaryl; wherein each of the aryl and heteroaryl represented by R3 may be substituted; n is an integer of 0 to 3; and a dotted line represents a single bond or a double bond.