| 主权项 |
1. A compound having the formula:or a pharmaceutically acceptable salt thereof,wherein:
Q is: and
Y1 is CH and Y2 is N,Y1 is N and Y2 is CH, orY1 is N and Y2 is N; or Q is: and
Z is N, Y1 is CH and Y2 is CH; A is phenyl, 5 or 6-membered heteroaryl, 5 to 7-membered monocyclic cycloalkyl or 5 to 7-membered heterocycloalkyl, each of which can be optionally substituted with up to four R5 groups; V is N or —C(R4)—; W is N or —CH—; X is —(CHR8)n—O— or —C(O)—O—, R1 represents up to 4 optional ring substituents, which can be the same or different, and are independently selected from halo, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl) and —CN; R2 is —C(O)N(R6)(R7) or —C(O)O—(C1-C6 alkyl); R3 is H, 4- to 6-membered heterocycloalkyl, 5 or 6-membered heteroaryl, —N(R11)2, halo, —CN, —N(R11)2, —C(O)O—(C1-C6 alkyl) or —N(R9)—S(O)n—R10, wherein said 5 or 6-membered heterocycloalkyl can optionally have one of its ring carbon atoms replaced with a carbonyl group; R4 is selected from H, halo, C1-C6 alkyl, 3 to 7-membered monocyclic cycloalkyl, C1-C6 haloalkyl, —O—(C1-C6 alkyl), —C(OH)—C(O)OR11 and —O—(C1-C6 haloalkyl); each occurrence of R5 is independently selected from H, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—(C1-C6alkyl), —O—(C1C6 haloalkyl) and —CN, wherein said C1-C6alkyl group can be optionally substituted with —OH or —N(R11)2; R6 and R7 are each independently selected from hydrogen, —C(O)R11, —C(O)OR11, —C(O)C(O)OR11, C1-C6 alkyl, C1-C6 hydroxyalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, 3 to 7-membered monocyclic heterocycloalkyl and 5 or 6-membered monocyclic heteroaryl; each occurrence of R8 is independently selected from H, halo, —OH, C1-C6 alkyl, C1-C6 hydroxyalkyl, phenyl, 5 or 6-membered monocyclic heteroaryl, —N(R11)2, C1-C6 haloalkyl, —(C1-C3 alkylene)p-(3 to 7-membered monocyclic cycloalkyl), —(C1-C3 alkylene)p—O—(C1-C6 alkyl), —(C1-C3 alkylene)p—N(R11)2, —(C1-C3 alkylene)—NHC(O)—(C1-C6 alkyl), —(C1-C3 alkylene)—OC(O)(C1-C6 alkyl)NHC(O)O—(C1-C6 alkyl), —(C1-C3 alkylene)—OC(O)—(3 to 7-membered monocyclic heterocycloalkyl), —(C1-C3 alkylene)—NHC(O)(3 to 7-membered monocyclic heterocycloalkyl), —CH(O—(C1-C6 alkyl))2, —O—(C1-C6 haloalkyl), —C(O)OR11, —C(O)N(R11)2, —CH2OC(O)CH(NH2)—(C1-C6 alkyl), —NHS(O)2—(C1-C6 alkyl), —CH2NHCH(R11)C(O)OR11, —NR11—(C1-C3 alkylene)—N(R11)2, —NR11—(C1-C3 alkylene)-(3 to 7-membered monocyclic heterocycloalkyl), —NR11—(C1-C6 hydroxyalkyl) and —CN; R9 is selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, benzyl, —(C1-C3 alkylene)-(3 to 7-membered monocyclic cycloalkyl) and 3 to 7-membered monocyclic cycloalkyl, wherein said C1-C6 alkyl group can be optionally substituted with a group selected from —N(R11)2, —OR11, —COOH, —C(O)N(R11)2, —S(O)2N(R11)2 and 3 to 7-membered monocyclic heterocycloalkyl and wherein the phenyl moiety of said benzyl group can be optionally substituted with a boronic acid group; R10 is selected from H, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, 3 to 7-membered monocyclic heterocycloalkyl and 5 or 6-membered monocyclic heteroaryl, wherein said C1-C6 alkyl group can be optionally substituted with a group selected from —N(R11)2, —OR11, —COOH, —C(O)N(R11)2, and —S(O)2N(R11)2; each occurrence of R11 is independently selected from H, C1-C6 alkyl, and 3 to 7-membered monocyclic cycloalkyl; each occurrence of n is 1, 2 or 3; and each occurrence of p is 0 or 1. |
