STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING SYNTHETIC PHOSPHORYLATED PEPTIDES

摘要

Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

主权项

1. A method of treating a disease or condition comprising administering a pharmaceutical composition comprising amorphous calcium carbonate (ACC) and at least one component selected from phosphorylated peptides comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:9, SEQ ID NO:17, SEQ ID NO:24, SEQ ID NO:25, and any homologues, variants, derivatives and fragments thereof; to a subject in need thereof.