METHODS FOR MAKING COMPOSITIONS FOR IMPROVING SKIN CONDITIONS

摘要

The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.

主权项

1. A method of making a fluid composition, the method comprising the steps of:
a) combining mannitol with a physiologically-acceptable buffer to make a mannitol-buffered solution, wherein the mannitol is present in at about 0.5% (w/v) to about 5% (w/v) of the solution; b) combining a hyaluronan polymer with the mannitol-buffered solution to hydrate the hyaluronan polymer, wherein the hyaluronan polymer is present at a concentration of about 11.5 mg/mL to about 15.5 mg/mL and wherein the hyaluronan polymer is substantially uncrosslinked.