T REGULATORY CELLS AND USES THEREOF

摘要

The present application relates to generation of regulatory T cells, particularly those generated in the presence of anti-CD80 and anti-CD86 antibodies. The present application also relates to uses of the regulatory T cells in treating subjects undergoing organ transplantation. The present application also relates to uses of the regulatory T cells in treating subjects undergoing tissue grafts. Regulatory T cells may be administered to a subject along with one or more antibodies.

主权项

1. A method of treating a condition in a subject mediated by an immune response which comprises administering to the subject a composition comprising antibodies, or antigen-binding fragments thereof, that specifically bind to CD80 and CD86, wherein administration of the antibodies, or antigen-binding fragments thereof, induce generation of a population of regulatory T-lymphocytes.