发明名称 |
Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure |
摘要 |
The present invention relates to a dengue virus-specific siRNA, a high-efficiency double helix oligo-RNA structure comprising the siRNA, and a composition for suppressing the proliferation of dengue virus comprising the RNA structure. The double helix oligo-RNA structure has a structure in which a hydrophilic material and a hydrophobic material are grafted on both ends of a double helix RNA (siRNA) via a simple covalent bond or a linker-mediated covalent bond so that the double helix oligo-RNA structure is efficiently delivered into cells, and can be transformed into a nanoparticle type by a hydrophobic interaction of the double helix RNA structures in an aqueous solution. The siRNA included in the double helix oligo-RNA structure specifically acts on the serotype of all dengue viruses. In addition, the present invention relates to a method for preparing the double helix oligo-RNA structure, and a pharmaceutical composition containing the double helix oligo-RNA structure for preventing or treating a dengue virus infection. |
申请公布号 |
AU2014284835(A1) |
申请公布日期 |
2016.02.18 |
申请号 |
AU20140284835 |
申请日期 |
2014.07.04 |
申请人 |
BIONEER CORPORATION |
发明人 |
YANG, JOO SUNG;KIM, WOO SEOK;CHOI, SOON JA;PARK, HAN OH |
分类号 |
C12N15/113;A61K48/00;A61P31/12 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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