Methods And Compositions For Treatment Of Interferon-Resistant Tumors

摘要

The present invention provides a method for the treatment of interferon resistant bladder tumors through the use of a non-replicating agent which induces human cells to express interferon species. In particular it is noted that inducing interferon expression in the patient's body possesses properties not associated with recombinant produced, intravenously-administered interferon proteins. The present invention further provides compositions useful in the treatment of bladder cancer resistant to treatment with intravenous interferon polypeptide, by using a non-replicating agent which induces human cells to express interferon species, e.g., an antigenic, replication-deficient virus optionally carrying an interferon transgene.

主权项

1. A composition of matter comprising: a non-interferon agent which induces interferon production in human cells which are exposed to it, said agent being replication-deficient, said agent formulated in normal saline as a non-emulsified suspension suitable for intravesical irrigation, said formulation providing said agent in an amount sufficient to induce interferon production in human bladder cells, said formulation further providing said agent in an amount effective to treat non-muscle invasive bladder cancer.