| 主权项 |
1. A method for treating cancer in a human subject comprising administering to a patient in need a compound having the structure:or an N-oxide, N,N′-dioxide, N,N′,N″-trioxide, or a pharmaceutically acceptable salt thereof,
wherein: R1 and R2 are independently hydrogen, optional substituted alkyl, halogen, optional substituted amine, NH2, optional substituted alkyoxy, optional substituted thioalkyl, CF3S optional substituted alkylsulfinyl or optional substituted alkylsulfonyl; Z′ is N or C; Rm is C1-6 alkyl, or halogen substituted C1-6 alkyl; and R3 is independently a C1-6 alkyl, halogen substituted C1-6 alkyl, halogen substituted C1-6 alkoxy, or C3-10cycloalkyl; or, Rm and R3 are joined to form a five to seven membered carbocycle; and n is 1-4; that (i) stabilizes a protein kinase in the inactive state and (ii) is not an ATP competitive inhibitor of the protein kinase in the active state; and wherein the cancer is selected from melanoma, breast cancer, pancreatic cancer, lung cancer, kidney cancer, and colon cancer. |
