Photocleavable linker

摘要

There are provided, inter alia, photolabile compounds and methods useful for the formation of dimers of biological molecules and subsequent dissociation of the dimers.

主权项

1. A method for forming a FK506 binding protein (FKBP) dimer, wherein each FKBP of the dimer is fused to a peptide, said method comprising:
(i) contacting a first FKBP fused to a peptide and a second FKBP fused to a peptide with a compound of Formula (I); and (ii) allowing said compound to bind to said first FKBP fused to a peptide and said second FKBP fused to a peptide, thereby forming said FKBP dimer comprising a link between said first FKBP fused to a peptide and said second FKBP fused to a peptide;thereby forming a FKBP dimer, wherein each FKBP of the dimer is fused to a peptide;
wherein,
said compound of Formula (I) has the structure wherein,
L1 is a photocleavable linker, andz1 and z2 are each independently an integer in the range 0 to 6.