BIOSYNTHESIS AND USES OF PROLINE/ALANINE RANDOM COIL POLYPEPTIDES

摘要

PROBLEM TO BE SOLVED: To provide large polypeptides having true random coil conformation.SOLUTION: A drug conjugate comprising (i) a biosynthetic random coil polypeptide or polypeptide segment comprising an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least 50 proline (Pro) and alanine (Ala) amino acid residues, and (ii) a drug selected from the group consisting of: (a) a biologically active protein or a polypeptide that comprises or that is an amino acid sequence that has or mediates a biological activity; and (b) a small molecule drug.SELECTED DRAWING: None