Compositions and Methods Comprising Celecoxib or Related Compounds and Dextromethorphan

摘要

Neurological disorders may be treated by administering a therapeutically effective amount of dextromethorphan and a therapeutically effective amount of a compound such as celecoxib that inhibits the metabolism of dextromethorphan, to a person in need thereof. The two compounds may be administered separately, or in a single dosage form or composition as described herein.

主权项

1. A method of inhibiting metabolism of dextromethorphan for a therapeutic use of dextromethorphan, comprising administering celecoxib to a human being in need of a therapeutic use of an elevated plasma level of dextromethorphan, wherein the human being is an extensive metabolizer of dextromethorphan, and wherein dextromethorphan is present in the body of the human being at the same time as celecoxib.