PROTEASE MODULATING WOUND INTERFACE LAYER FOR USE WITH NEGATIVE PRESSURE WOUND THERAPY

摘要

Systems, methods, and apparatuses for modulating proteases including matrix metalloproteinase (MMP), elastase, and bacterial protease in a negative pressure therapy system are described. A mesh having a sacrificial substrate is included. The sacrificial substrate includes a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings. The openings of the plurality of openings have an average area between about 0.5 mm2 and about 20 mm2 to permit the flow of negative pressure through the mesh. The sacrificial substrate can also include oxidized regenerated cellulose.

主权项

1. A mesh for modulating proteases in a negative pressure therapy system, comprising:
a sacrificial substrate including a plurality of collagen fibers reinforced with a supporting material and intersecting with each other to form a network of collagen fibers having a plurality openings; and wherein the openings of the plurality of openings have an average area between about 0.2 mm2 and about 20 mm2 to permit the flow of negative pressure through the mesh.