主权项 |
1. A compound of formula I, wherein
Ak represents C1-4 alkyl;R1 represents trimethylsilyl, C2-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, phenyl, Het1 or Het2, which latter seven groups are optionally substituted by one or more substituents selected from the group consisting of C1-2 alkyl, halo, hydroxy, and C1-2 alkoxy;R2 and R3, together with the C-atoms to which they are attached, form a fused phenyl or pyridyl ring, which latter two rings are optionally substituted by one or more substituents selected from the group consisting of C1-3 alkyl, C1-3 haloalkyl, cyano and halo,or one of R2 and R3 represents H, halo, cyano, C1-3 alkyl or C1-3 haloalkyl and the other independently represents halo, cyano, C1-3 alkyl or C1-3 haloalkyl,or R2 and R3 together combine to form C3-5 alkylene or C3-5 alkenylene, which latter two groups are optionally substituted by one or more substituents selected from the group consisting of C1-3 alkyl, C1-3 haloalkyl, cyano and halo;X1 represents N or CH;X2 and X3 both represent CRZ or one of X2 and X3 represents N and the other represents CRZ;RZ represents H, halo, cyano, C1-3 alkyl or C1-3 alkoxy, which latter two groups are optionally substituted by one or more halo atoms;R4 represents
-Q1-[CH2(CH2)0-1CH2—O]1-12—CH2(CH2)0-1CH2—R6a,-Q2-C(R6c)(R6d)—[C1-5 alkylene]-R6a or—S(O)nR6b;R5 represents C1-3 alkoxy or C1-3 alkyl, which latter two groups are optionally substituted by one or more halo atoms, or R5 represents H, cyano, halo or C2-3 alkynyl;R6a represents OR7a or N(R7b)R7c;R6b represents C1-8 alkyl, C3-8 cycloalkyl, phenyl, Het1 or Het2, which latter five groups are optionally substituted by one or more substituents selected from the group consisting of hydroxyl, C1-3 alkyl and C1-3 alkoxy;R6c and R6d independently represent H or methyl;R7a to R7c independently represent H or C1-4 alkyl optionally substituted by one or more halo atoms, or R7b and R7c, together with the N-atom to which they are attached, form a 4- to 7-membered heterocyclic group that is fully saturated, partially unsaturated or fully aromatic and which heterocyclic group contains one N atom (the atom to which R7b and R7c are attached) and, optionally, one or more further heteroatoms selected from O, S and N, and which heterocyclic group is optionally substituted by one or more substituents selected from the group consisting of halo, hydroxy, oxo, C1-4 alkyl and C1-4 alkoxy;Q1 and Q2 independently represent C(O)NH, O or S(O)p;n and p independently represent 0, 1 or 2,Het1 represents 5- or 6-membered heterocyclic group that is fully aromatic, which group contains one or more heteroatoms selected from the group consisting of N, O and S; andHet2 represents a 4- to 7-membered heterocyclic group that is fully saturated or partially unsaturated, which group contains one or more heteroatoms selected from the group consisting of N, O and S; or a pharmaceutically acceptable salt, solvate or isotopic derivative thereof. |