High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
申请公布号
WO2016022994(A2)
申请公布日期
2016.02.11
申请号
WO2015US44356
申请日期
2015.08.07
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人
RING, AARON MICHAEL;KRUSE, ANDREW;MANGLIK, AASHISH;WEISSMAN, IRVING L.;MAUTE, ROY LOUIS;MCCRACKEN, MELISSA N.;GORDON, SYDNEY