| 发明名称 |
BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS AND USES THEREOF |
| 摘要 |
Disclosed herein are methods, compositions, and kits for treating a B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor. Also disclosed herein are methods, compositions, and kits for treating a BTK-resistant B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor. |
| 申请公布号 |
US2016038495(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201514820434 |
申请日期 |
2015.08.06 |
| 申请人 |
Pharmacyclics LLC |
发明人 |
KUO Hsu-Ping;HSIEH Hsin-Kang;CHANG Betty;XUE Ling;BALASUBRAMANIAN Sriram;CHEUNG Leo |
| 分类号 |
A61K31/519;A61K31/4196;A61K38/00;A61K31/426;A61K31/454;A61K38/07;A61K45/06;A61K31/4164 |
主分类号 |
A61K31/519 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a B-cell malignancy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination comprising a BTK inhibitor and an anticancer agent, wherein the anticancer agent inhibits MALT1, MCL-1, or IDH1. |
| 地址 |
Sunnyvale CA US |
