发明名称 |
processo aperfeiçoado para peguilacao de proteínas |
摘要 |
The present invention relates to a process for improving pegylation reaction yield of r-metHuG-CSF comprising conjugating r-metHuG-CSF to a PEG aldehyde at a free amine moiety at the N terminal end on the G-CSF in presence of a reducing agent in a pegylation buffer solution comprising a polyol having the formula CnH2n+2On where n is from 3 to 6, or a carbohydrate, or a derivative thereof wherein the concentration of said polyol or carbohydrate or derivative thereof is in the range of 0.1% to 10% w/w. |
申请公布号 |
BRPI0919827(A2) |
申请公布日期 |
2016.02.10 |
申请号 |
BR2009PI19827 |
申请日期 |
2009.05.04 |
申请人 |
USV LIMITED |
发明人 |
ARUNA KHARE;DIVYA LAL SAKSENA;DIGAMBER SHRIPATI PAWAR;DILIP KUMAR RANA;DINESHI KUMAR PALIWAL;MURALIDHARAN CHANDRAKESAN;NIKHIL UMESH MOHE;NILESH DAGDU PATIL;PANKAJ PRABHAKAR MALPURE;RADHARKRISHNAN VENKATSUBRAMANIAN TARUR;RAKESH SHEKHAWAT;SAGAR SATYANARAYAN ZAWAR |
分类号 |
A61K47/48;C07K14/535 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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