NUCLEIC ACID FOR CODING CHIMERIC ANTIGEN RECEPTOR PROTEIN AND T LYMPHOCYTE FOR EXPRESSION OF CHIMERIC ANTIGEN RECEPTOR PROTEIN

摘要

A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287th to 302th amino acid epitopes of a human epidermal growth factor receptor (EGFR).