发明名称 |
EGFRvIII SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY |
摘要 |
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from an EGFRvIII monoclonal antibody, conferring specific immunity against EGFRvIII positive cells. The TCR KO engineered immune cells endowed with such CARs are particularly suited for treating lung cancer, anal cancers and glioblastoma multiforme. |
申请公布号 |
WO2016016341(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
WO2015EP67439 |
申请日期 |
2015.07.29 |
申请人 |
CELLECTIS |
发明人 |
SCHIFFER-MANNIOUI, CECILE |
分类号 |
A61K48/00;C07K16/28;C07K16/30;C07K19/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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