VACCINE DELIVERY DEVICES

摘要

This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.

主权项

1. A vaccine delivery device comprising:
(a) a container having a portion of its surface define porous openings that restrict intact cells from passing in and out of said container and that permit antibodies to pass in and out of said container, (b) a vaccine depot comprising an antigen and located within said container, and (c) a barrier material located within said container in a position wherein said antigen of said vaccine depot must travel through said barrier material to reach said porous openings, wherein said barrier material allows free antibodies and free antigen to pass through said barrier material, and wherein said barrier material prevents antibody-antigen complexes from passing through said barrier material.