A METHOD FOR IMPROVING DISEASE DIAGNOSIS USING MEASURED ANALYTES

摘要

Methods for improving clinical diagnostic tests are provided, along with associated diagnostic techniques.

主权项

1. A method for diagnosing a disease, comprising the steps of:
a) determining the concentrations of at least three predetermined analytes in a blind sample from a subject; b) selecting one or more meta-variable associated with the subject, which varies in a population associated with the subject for members of the population who are known either to have or not have the disease; c) transforming the concentrations of the analytes as a function of one or more population distribution characteristics and the one or more meta-variables to compute a pseudo-concentration that represents each analyte; d) comparing the pseudo-concentrations to a training set model of pseudo-concentrations determined for members of the population who are known either to have or not have the disease; and e) determining whether the comparison indicates that the subject has the disease.