Immunogenic Composition in Emulsion Form

摘要

The present invention relates to an immunogenic composition comprising a continuous aqueous phase and a dispersed phase as droplets and comprising:
an amphiphilic lipid,a solubilizing lipid comprising at least one fatty acid glyceride,a co-surfactant comprising at least one chain consisting of alkylene oxide units,a surfactant bearing an antigen of the following formula (I):;(L1-X1—H1—Y1)v-G-Z1—Ag  (I),;to its preparation method and its uses, notably for producing antibodies, as a drug or in an immunization method.

主权项

1. An immunogenic composition comprising a continuous aqueous phase and a dispersed phase as droplets and comprising:
an amphiphilic lipid, a solubilizing lipid comprising at least one fatty acid glyceride, a co-surfactant comprising at least one chain consisting of alkylene oxide units, a surfactant bearing an antigen of the following formula (I):
(L1-X1—H1—Y1)v-G-Z1—Ag  (I), wherein:
L1 represents a lipophilic group,X1, Y1, Z1 and G represent independently a binding group,H1 represents a hydrophilic group comprising a polyalkoxylated chain,v is an integer from 1 to 8, andAg represents an antigen,wherein the molar ratio of the surfactant bearing an antigen of formula (I) over the sum of the co-surfactant and of the surfactant bearing an antigen of formula (I) is from 0.01% to 5%.