INHIBITION OF HSV-1-ASSOCIATED CORNEAL NEOVASCULARIZATION USING INHIBITORS OF CYCLIN-DEPENDENT KINASE 9

摘要

Provided are methods of preventing and/or treating herpes simplex virus-1 (HSV-l)-associated ocular neovascularization comprising administering a cyclin-dependent kinase (CDK) inhibitor. Preferably a CDK9 inhibitor, such as flavopiridol or dichlorobenzimidazole-l-β-D-ribofuranoside (DRB), is administered to prevent and / or treat HSV-l-associated ocular neovascularization. Additionally, methods of inhibiting angiogenesis and HSV-1 replication comprising the use of a cyclin-dependent kinase inhibitor are provided.