COMPOSITIONS AND METHODS FOR INCREASING DEXTROMETHORPHAN PLASMA LEVELS AND RELATED PHARMACODYNAMIC EFFECTS

摘要

This disclosure relates to methods of increasing dextromethorphan plasma levels comprising co-administering hydroxybupropion, or a prodrug thereof, and dextromethorphan to a human being in need of treatment with dextromethorphan. Dosage forms, drug delivery systems, and methods related to dextromethorphan and hydroxybupropion or a prodrug of bupropion are also disclosed.

主权项

1. A method of increasing dextromethorphan plasma levels in a human being that is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, comprising co-administering hydroxybupropion or bupropion with dextromethorphan to a human being once or twice a day for at least eight consecutive days, wherein the daily dose of dextromethorphan is about 40 mg to about 600 mg, and co-administering hydroxybupropion or bupropion with dextromethorphan results in an AUC0-12 of dextromethorphan that, on the eighth day, is at least about 20 times the AUC0-12 that would be achieved by administering the same amount of dextromethorphan without hydroxybupropion or bupropion for eight consecutive days.