| 主权项 |
1. A method of treating a disease in a patient in need of such treatment, said method comprising administering a therapeutically effective amount of a compound to said patient, wherein said disease is selected from the group consisting of a neurological disease, pain, migraine, ischemic injury, brain ischemia, stroke, a neurodegenerative disease, a mood disorder, depression, and decompression sickness; and wherein said compound has the formula: wherein L1 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; L2 is a bond, —O—, —S—, —NH—, —C(O)—, —C(O)NH—, —NHC(O)—, —S(O)—, or —S(O)2—; R1, R2, R4, and R5 are independently hydrogen, halogen, —CF3, —CCl3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCH3, —OCF3, —OCHF2, —N3,—C(CH3)3, —OCH2CCH, —NHCH2CCH, —NHCH3, —N(CH3)2, —NHS(O)CH3, —C(O)CH3, —CH3, —CH2CCH, —NHC(O)CH3, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
where R4 and R5 may optionally be joined to form a substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl; R3 is hydrogen, halogen, —CX3, —CN, —SO2Cl, —SO1R10, —SOvNR7R8, —NHNH2, —ONR7R8, —NHC═(O)NHNH2, —NHC═(O)NR7R8, —N(O)m, —NR7R8, —C(O)R9, —C(O)OR9, —C(O)NR7R8, —OR10, —NR7SO2R10, —N(R7)C═(O)R9, —NR7C(O)—OR9, —NR7OR9, —OCX3, —OCHX2, —OPO(OH)2, —PO(OH)2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R7, R8, R9, and R10, are independently hydrogen, oxo, halogen, —C(O)CH3, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)CH3, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; where R7 and R8 are bonded to the same nitrogen atom, they may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; W is —O—, —S—, —S(O)—, —S(O)2—, or —C(R4)(R5)—; y is 0 or 1; m and v are independently 1 or 2; n is independently 0 to 4; t1 and t2 are independently 1 to 4; X is independently —Cl, —Br, —I, or —F. |
