| 主权项 |
1. A compound chosen from:
N-(4-{[2-(azepan-1-yl)ethyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-{4-[(2-hydroxypropyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-(4-{[2-(2-oxoimidazolidin-1-yl)ethyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-(4-{[2-(tetrahydro-2H-pyran-2-yl)ethyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-(4-{[(2-methyltetrahydrofuran-2-yl)methyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-(4-{[2-methyl-2-(morpholin-4-yl)propyl]carbamoyl}phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-{4-[(1-oxa-8-azaspiro[4.5]dec-3-ylmethyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2-oxa-7-azaspiro[3.5]non-7-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(hexahydrofuro[3,2-c]pyridin-5(4H)-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(hexahydro-5H-furo[2,3-c]pyrrol-5-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,6-dioxa-9-azaspiro[4.5]dec-9-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2-oxa-6-azaspiro[3.3]hept-6-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2-oxa-6-azaspiro[3.5]non-6-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2-oxa-7-azaspiro[4.4]non-7-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(10,10-difluoro-2,7-diazaspiro[4.5]dec-2-yl)carbonyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(3-cyano-1-oxa-8-azaspiro[4.5]dec-8-yl)carbonyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(7-oxa-2-azaspiro[3.5]non-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(1-oxa-7-azaspiro[4.4]non-7-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(10-fluoro-2,7-diazaspiro[4.5]dec-2-yL)carbonyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(3,9-diazaspiro[5.5]undec-3-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,7-diazaspiro[4.5]dec-7-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,8-diazaspiro[4.5]dec-8-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(7-azaspiro[3.5]non-1-ylcarbamoyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2-azaspiro[3.3]hept-5-ylcarbamoyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(1R,5S)-3-azabicyclo[3.1. 0]hex-6-ylcarbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-(6-{[(7R)-octahydropyrrolo[1,2-a]pyrazin-7-ylmethyl]carbamoyl}pyridazin-3-yl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,6-diazaspiro[3.5]non-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,7-diazaspiro[3.5]non-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,6-diazaspiro[3.4]oct-6-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(2-oxa-9-azaspiro[5.5]undec-3-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(1-oxa-8-azaspiro[4.5]dec-2-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(1-oxa-8-azaspiro[4.5]dec-3-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,7-diazaspiro[3.5]non-7-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,8-diazaspiro[4.5]dec-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-(6-{[3-(azetidin-3-yl)pyrrolidin-1-yl]carbonyl}pyridazin-3-yl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(1-oxa-8-azaspiro[4.5]dec-3-ylcarbamoyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a][1,4]diazepin-3-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(6-azaspiro[2.5]oct-1-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(5-oxa-2-azaspiro[3.4]oct-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-(6-{[(4-fluoropiperidin-4-yl)methyl]carbamoyl}pyridazin-3-yl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(2,6-diazaspiro[3.3]hept-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(6-oxa-2-azaspiro[3.4]oct-7-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-[6-(5-oxa-2-azaspiro[3.5]non-2-ylcarbonyl)pyridazin-3-yl]-1,3-dihydro-2H-isoindole-2-carboxamide; N-(6-{[1-(trifluoromethyl)-2,8-diazaspiro[4.5]dec-2-yl]carbonyl}pyridazin-3-yl)-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(7-azaspiro[3.5]non-2-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide; N-{6-[(5,6,7,8-tetrahydro-4H-[1,2,3]triazolo[1,5-a][1,4]diazepin-3-ylmethyl)carbamoyl]pyridazin-3-yl}-1,3-dihydro-2H-isoindole-2-carboxamide;and pharmaceutically acceptable salts thereof. |
