Controlled disintegrating implantable medical devices

摘要

Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed. The devices include a body structure including an active agent, erodable particles acting as a carrier of the active agent, and an erodable binder. The binder releasably binds the particles together such that after implantation the binder erodes to release the particles.

主权项

1. An implantable medical device consisting of:
a body structure consisting of erodable particles and an erodable binder releasably binding the particles together such that after implantation the binder erodes to release the particles, wherein the particles have a slower erosion rate than the binder, and wherein the particles are dispersed in the binder, wherein the particles consist of a bioerodable polymer and an active agent, wherein the bioerodable polymer acts as a carrier of the active agent, wherein the binder consists of a bioabsorbable polymer, wherein the bioerodable polymer comprises a polymer selected from the group consisting of poly(ethylene oxide), poly(acrylamide), acrylic polymers and copolymers other than polyacrylates, poly(vinyl alcohol), tyrosine based polycarbonates, cellulose acetate, and polyethylene glycol; and optionally a coating over the body structure consisting of a coating polymer and a drug, wherein the device is a stent adapted to be implanted in a bodily lumen.