| 发明名称 |
Human growth hormone receptor antagonist antibodies and methods of use thereof |
| 摘要 |
The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation. |
| 申请公布号 |
US9249224(B2) |
申请公布日期 |
2016.02.02 |
| 申请号 |
US201214367483 |
申请日期 |
2012.12.10 |
| 申请人 |
RINAT NEUROSCIENCE CORP. |
发明人 |
Siebel Sara Iva;Pascua Edward Derrick;Lin Chia-Yang;Chaparro Riggers Javier Fernando |
| 分类号 |
C07K16/28;A61K39/395;A61K39/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
Wang Susan L. |
| 主权项 |
1. An isolated growth hormone receptor (GHR) antagonist antibody that specifically binds to GHR and comprises: a heavy chain variable region (VH) comprising a VH complementary determining region one (CDR1), VH CDR2, and VH CDR3 of the VH comprising the amino acid sequence shown in SEQ ID NO: 8; and a light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL comprising the amino acid sequence shown in SEQ ID NO: 7. |
| 地址 |
South San Francisco CA US |
