System Error Compensation Of Analyte Concentration Determinations

摘要

During analyte analysis, errors may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The present invention introduces the determination of a pseudo-reference concentration determined during the analysis as a substitute for the true relative error and uses an anchor parameter to compensate for the system error in the analysis-determined pseudo-reference concentration.

主权项

1. A method for determining an analyte concentration in a sample, comprising:
generating at least one output signal from a sample; measuring at least one analyte responsive output signal from the sample; determining a pseudo-reference concentration value from the at least one analyte responsive output signal, where a pseudo-reference concentration value is a substitute for true relative error; determining at least one anchor parameter in response to the pseudo-reference concentration value, where the at least one anchor parameter compensates for system error, incorporating the at least one anchor parameter into a compensation relationship; and determining a final compensated analyte concentration of the sample in response to the compensation relationship.