| 摘要 |
PROBLEM TO BE SOLVED: To provide, generally, cancer therapy, and more specifically, methods for preventing or minimizing neurotoxicity associated with cancer therapy using DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs.SOLUTION: Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme in both nervous and non-nervous tissues within the patient and thereafter administering 5-FU or a 5-FU prodrug, where the level of 5-FU or 5-FU generated from the prodrug is in substantial excess of the DPD inhibitor in the patient. |
