| 发明名称 |
HYPOSIALYLATION DISORDERS |
| 摘要 |
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST. |
| 申请公布号 |
US2016025717(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201414775507 |
申请日期 |
2014.03.13 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER ;EMORY UNIVERSITY |
发明人 |
Huizing Marjan;Gahl William A.;Carrillo-Carrasco Nuria;He Miao;Li Xueli;Jiang Rong |
| 分类号 |
G01N33/53;A61K45/06 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for diagnosing a hyposialylation disorder in a subject, comprising
measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample from the subject, wherein Thomsen-Friedenreich antigen is N-acetylgalactosamine (GalNAc) linked to galactose (Gal); and determining the ratio of T to ST; wherein a ratio of T to ST of about 0.052 or greater diagnoses the subject as having the hyposialylation disorder. |
| 地址 |
Bethesda MD US |
